GOE 6983
Go 6983
CAS: 133053-19-7
Molecular Formula: C26H26N4O3
GOE 6983 - Names and Identifiers
GOE 6983 - Physico-chemical Properties
| Molecular Formula | C26H26N4O3 |
| Molar Mass | 442.51 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| Boling Point | 709.0±60.0 °C(Predicted) |
| Solubility | DMSO 59 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | powder |
| Color | red |
| pKa | 8.02±0.60(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| MDL | MFCD04040031 |
| In vitro study | Gö6983 (300μm) acts on NIH3T3 cells transfected with pkcμ, inhibiting pkcμ autophosphorylation by 20%. Cardiac reperfusion PMNs and Gö 6983 (100 nM), left ventricular development pressure (LVDP) and LVDP rates recovered to 89% and 74% of baseline values, respectively, significantly higher than PMNs alone. Compared with cardiac ischemia-reperfusion (I/R)+ PMN, gö6983 (100 nM) significantly reduced PMNs adhesion to endothelial cells and infiltration into myocardium, and the release of superoxide from PMNs was significantly inhibited, up to 90%. In the presence of PMNs, Gö 6983 reduces post-I/R myocardial contractile dysfunction, which may be partially related to reduced superoxide production. The Gö 6983 significantly inhibited antigen-induced superoxide release from leukocytes of patients who had previously been allergic to tree pollen. Gö 6983 acts on human vascular tissue to inhibit intracellular Ca(2 +) accumulation, indicating the mechanism of its vasodilatory properties. Go-6983(1 μm) in combination with Ro-31-8425(390 nM) in PGSMCs slightly inhibited the activity of PLD2 induced by Angiotensin II. Gö 6983 is a subtype-specific PKC inhibitor that targets the ATP binding site. Gö 6983 inhibits Δpfpkb activity with an IC50 of 1 μm. In Gö 6983(5 μm) treated cells, the number of next cell cycle loops was significantly reduced compared to control cultures. Gö 6983 (5 μm) treatment of P. falciparum cultures reduced new ring formation by nearly 60%. |
| In vivo study | In the mouse lung B16BL6 tumor model, Go6983 (22.0 μg/mouse, I. v.) strongly inhibited tumor metastasis by 51.2%. |
GOE 6983 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
GOE 6983 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.26 ml | 11.299 ml | 22.598 ml |
| 5 mM | 0.452 ml | 2.26 ml | 4.52 ml |
| 10 mM | 0.226 ml | 1.13 ml | 2.26 ml |
| 5 mM | 0.045 ml | 0.226 ml | 0.452 ml |
Last Update：2024-01-02 23:10:35
GOE 6983 - Reference Information
| biological activity | Go 6983 (GOE 6983, gö6983) is a pan-PKC inhibitor that acts on pkcα, PKC beta, PKC gamma and PKC Delta, IC50 were 7 nM, 7 nM, 6 nM and 10 nM, respectively, and the effect on PKC ζ was slightly weak, and the activity of PKC was inhibited. |
| Target | Value |
| PKCγ (Cell-free assay) | 6 nM |
| PKCα (Cell-free assay) | 7 nM |
| PKCβ (Cell-free assay) | 7 nM |
| PKCδ (Cell-free assay) | 10 nM |
| PKCζ (Cell-free assay) | 60 nM |
Last Update：2024-04-09 20:48:19
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Product Name: Go 6983 Visit Supplier Webpage Request for quotationCAS: 133053-19-7
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Spot supply
Product Name: Go 6983 Visit Supplier Webpage Request for quotationCAS: 133053-19-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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